To do any reasonable damage at all i HAD to have at least weapon elemental damage and fire penetration.
I tested all of the active skills possible but the only ones that you can utilize to any satisfactory point were infernal blow(with lots of fire/elemental damage passives), flicker strike and spectral throw. For it i have leveled up a templar, duelist, ranger and a shadow and tested a huge variety of different approaches into benefitting from the unique modifiers in the item.